Detalhe da pesquisa
1.
Interleukin-15 Complex Treatment Protects Mice from Cerebral Malaria by Inducing Interleukin-10-Producing Natural Killer Cells.
Immunity
; 48(4): 760-772.e4, 2018 04 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-29625893
2.
Immunotherapeutic HCW9218 augments anti-tumor activity of chemotherapy via NK cell-mediated reduction of therapy-induced senescent cells.
Mol Ther
; 30(3): 1171-1187, 2022 03 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35051615
3.
Bifunctional TGF-ß trap/IL-15 protein complex elicits potent NK cell and CD8+ T cell immunity against solid tumors.
Mol Ther
; 29(10): 2949-2962, 2021 10 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-34091051
4.
T cell sensing of antigen dose governs interactive behavior with dendritic cells and sets a threshold for T cell activation.
Nat Immunol
; 9(3): 282-91, 2008 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-18204450
5.
First-in-human phase 1 clinical study of the IL-15 superagonist complex ALT-803 to treat relapse after transplantation.
Blood
; 131(23): 2515-2527, 2018 06 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29463563
6.
ALT-803 Transiently Reduces Simian Immunodeficiency Virus Replication in the Absence of Antiretroviral Treatment.
J Virol
; 92(3)2018 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29118125
7.
ALT-803, an IL-15 superagonist, in combination with nivolumab in patients with metastatic non-small cell lung cancer: a non-randomised, open-label, phase 1b trial.
Lancet Oncol
; 19(5): 694-704, 2018 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29628312
8.
An IL-15 superagonist/IL-15Rα fusion complex protects and rescues NK cell-cytotoxic function from TGF-ß1-mediated immunosuppression.
Cancer Immunol Immunother
; 67(4): 675-689, 2018 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-29392336
9.
A Subset of Latency-Reversing Agents Expose HIV-Infected Resting CD4+ T-Cells to Recognition by Cytotoxic T-Lymphocytes.
PLoS Pathog
; 12(4): e1005545, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-27082643
10.
Evaluation of the biological activities of the IL-15 superagonist complex, ALT-803, following intravenous versus subcutaneous administration in murine models.
Cytokine
; 107: 105-112, 2018 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29452720
11.
A Novel Fusion of ALT-803 (Interleukin (IL)-15 Superagonist) with an Antibody Demonstrates Antigen-specific Antitumor Responses.
J Biol Chem
; 291(46): 23869-23881, 2016 Nov 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27650494
12.
ImmunoPET and Near-Infrared Fluorescence Imaging of Pancreatic Cancer with a Dual-Labeled Bispecific Antibody Fragment.
Mol Pharm
; 14(5): 1646-1655, 2017 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28292180
13.
Therapeutic administration of IL-15 superagonist complex ALT-803 leads to long-term survival and durable antitumor immune response in a murine glioblastoma model.
Int J Cancer
; 138(1): 187-94, 2016 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26174883
14.
In Vivo Activation of Human NK Cells by Treatment with an Interleukin-15 Superagonist Potently Inhibits Acute In Vivo HIV-1 Infection in Humanized Mice.
J Virol
; 89(12): 6264-74, 2015 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-25833053
15.
ImmunoPET of tissue factor expression in triple-negative breast cancer with a radiolabeled antibody Fab fragment.
Eur J Nucl Med Mol Imaging
; 42(8): 1295-303, 2015 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-25801992
16.
Induction of durable remission by dual immunotherapy in SHIV-infected ART-suppressed macaques.
Science
; 383(6687): 1104-1111, 2024 Mar 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-38422185
17.
A novel interleukin-2-based fusion molecule, HCW9302, differentially promotes regulatory T cell expansion to treat atherosclerosis in mice.
Front Immunol
; 14: 1114802, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-36761778
18.
Immunotherapeutic approach to reduce senescent cells and alleviate senescence-associated secretory phenotype in mice.
Aging Cell
; 22(5): e13806, 2023 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36967480
19.
Predicting Ca2+ -binding sites using refined carbon clusters.
Proteins
; 80(12): 2666-79, 2012 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-22821762
20.
A phase I study evaluating the pharmacokinetics, safety and tolerability of an antibody-based tissue factor antagonist in subjects with acute lung injury or acute respiratory distress syndrome.
BMC Pulm Med
; 12: 5, 2012 Feb 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-22340260